"Caution: Persons taking medications that affect platelet aggregation (such as aspirin, warfarin, NSAIDs) or persons with bleeding disorders, such as peptic ulcers should consult a healthcare professional before using grape seed extract."
Nature's Way Premium Extract Grape Seed vcaps
"Caution: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this [resveratrol] or any dietary supplement."
BRI Resveratrol Extra Strength
"Side effects may include minor gastrointestinal upset, nausea, headache and fatigue and possible supplement-drug interactions with estrogens and anticoagulants."
Studies indicate that resveratrol changes gut microbiome and inhibits trimethylamine (TMA) production by gut bacteria.
New Research Topics (2016):
- Resveratrol and health - A comprehensive review of human clinical trials
Article (PDF Available) in Molecular Nutrition & Food Research 55(8):1129-41 · August 2011 with 1,188 Reads
DOI: 10.1002/mnfr.201100143 · Source: PubMed
Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.
In the Summary and Recommendations of this study (see #12) it states,
12 Summary and recommendations
The emerging data from human clinical trials conﬁrmswhat the past decade of in vitro and laboratory animalmodels have suggested; resveratrol has considerable poten-tial to improve health and prevent chronic disease inhumans. We believe the evidence is sufﬁciently strong toconclude that a single dose of resveratrol is able to inducebeneﬁcial physiologic responses, and that either weeks ormonths of resveratrol supplementation produces physiolo-gic changes that are predictive of improved health, especiallyin clinical populations with compromised health...
- Targeting gut microbiome to fight heart disease Date: April 5, 2016 Source: American Society for Microbiology Summary: A compound found in red wine, resveratrol, reduces the risk of heart disease by changing the gut microbiome, according to a new study. Cardiovascular disease remains the leading cause of death in industrialized societies including the United States, and the incidence is growing in developing countries.
… Resveratrol inhibits TMA production by gut bacteria... In our current study, we found that resveratrol can remodel the gut microbiota including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Prevotella, and increasing the relative abundance of Bacteroides, Lactobacillus, Bifidobacterium, and Akkermansia in mice," said Dr. Mi. "Resveratrol reduces TMAO levels by inhibiting the gut microbial TMA formation via remodeling gut microbiota. https://www.sciencedaily.com/releases/2016/04/160405105547.htm http://www.eurekalert.org/pub_releases/2016-04/asfm-ttg033116.php
- Therapeutic potential of resveratrol: the in vivo evidence
Joseph A. Baur and David A. Sinclair
Abstract | Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans. http://www.med.upenn.edu/baurlab/pdfs/Therapeutic_potential_of_resveratrol.pdf
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