Dimethylsulfidemia: its significance in extra-oral blood borne halitosis

Many topics were presented by MEBO’s experts in our conference, and the excitement in the room was palpable as the wide spectrum of topics were presented, from FMO3 and CYPs (P450s), dimethylsulfidemia (DMS), testing programs (breath test and TMAU kits handed out), quality of life and employment issues were presented and discussed. All attendees left feeling hopeful and thrilled to have been a part of such a cutting-edge body odor and halitosis discussions. To make it even more meaningful, to have enjoyed the experience with other sufferers with whom we bonded instantly, was nothing less than euphoric. Our most profound gratitude goes out to all the experts who shared their knowledge pro-bono with us, and whose compassion for our plight is immeasurably appreciated by us all.

In addition to Dr. Elizabeth Shephard’s presentation, we viewed the PowerPoint featured above created by MEBO Research’s Scientific Advisor. This PowerPoint presentation is complementary to a MEBO Research paper he is working on for publication, of which a shortened version of its abstract is noted below. We hope that this presentation is only the beginning of great things to come in the study of Dimethylsulfidemia.

Halitosis is estimated to be the third most common trigger for patients to seek dental care. 10-15% of all genuine halitosis cases are attributed to extraoral causes, of which blood borne halitosis appears to be the most common subtype. New evidence suggests that dimethyl sulfide is the most prevalent volatile implicated in extraoral blood borne halitosis. This conclusion was reached in 2007 by Tangerman and Winkel, who proposed a hitherto unknown metabolic condition, resulting in systemic presence of dimethyl sulfide in blood and alveolar breath, by way of explanation for this finding. This potential new metabolic condition remains unnamed and undefined. A new condition would perhaps come as little surprise after the hundreds of new metabolic conditions identified in recent decades following genome-phenome mapping. This paper reviews the knowledge base regarding the behaviour of dimethyl sulfide in physiological systems, and those disorders in which dimethylsulfidemia related blood borne halitosis is thought to have an aetiopathological role. A small amount of speculation is also offered regarding the possible nature of the above-mentioned metabolic condition.

See more articles and posts on sulfur compounds (some are not written in English):

• http://www.bloodbornebodyodorandhalitosis.com/search/label/sulfur%20compounds"
• http://www.ncbi.nlm.nih.gov/pubmed/3713901
• http://www.ncbi.nlm.nih.gov/pubmed/3724872
• http://www.ncbi.nlm.nih.gov/pubmed/3724864
• http://www.ncbi.nlm.nih.gov/pubmed/11255985
• http://www.ncbi.nlm.nih.gov/pubmed/11143967

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María de la Torre
Founder and Executive Director

A Public Charity
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maria.delatorre@meboresearch.org
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