Happy Holidays 2010

Merry Christmas and a

Happy New Year

MEBO and Eliapharma now offering single sample TMAU urine test for $80 plus fees and shipping

See Elipharma's website, "News and Events" Pages

Update 6

On Friday afternoon, December 17th,The Public Health Agency awarded Eliapharma Services, Inc., the Permit to import Human pathogen(s) into Canada. Shortly thereafter, I began to notify the 43 people already on the waitlist for the TMAU Urine Test through MEBO Research and Eliapharma, to inform them that they could fill out the application form.

MEBO-ELIAPHARMA TMAU TEST PROGRAM APPLICATION

This English and Spanish versions of this application was designed by MEBO Research's Technical Consultant, who volunteered to donate countless hours of intense work day in and day out on this holiday season, and I'm certain you will agree with me that he has done a very professional and impressive job indeed!

Well, now Eliapharma is offering yet another option of testing with only one sample for $80 instead of two samples for $110, representing a savings of $30.

We have received an overwhelmingly enthusiastic response, and I'm doing all I can to keep up with the demand, and it's been challenging to get to everyone on a timely basis. I have been informed by FedEx that most major shippers will be having their annual rate increase in January 2011, and that their rates are subject to change until purchased. I also notice that their fuel surcharge have also increased as the gas prices have been increasing at our local gas station.

For this reason, Eliapharma has offered us yet another option to encourage all sufferers of unusual and uncontrollable body odor to test. As originally posted in this blog, this lab has offered two samples per kit for $110 plus fees and shipping costs, with the option of including up to 4 more samples per kit at $60 each. Well, now Eliapharma is offering yet another option of testing with only one sample for $80 instead of two samples for $110, representing a savings of $30.

Hopefully, this will be particularly helpful for persons who live in countries further away from the lab in Canada resulting in higher shipping charge, and with not very favorable currency exchange rates. Nonetheless, anyone interested in participating in this program before the rates go up can fill out the application, and be placed on a waitlist with no obligation. I will try to clear the waitlist on a first come, first served basis as quickly as possible, as I keep in mind that the shipping rates will increase soon.

At the same time, it is a holiday season, and we look forward to enjoy this season with our loved ones. For those wishing to hold a conference call on any specific day of the holidays, please let me know, and I'll contact the ladies that customarily organize them.

Wishing everyone a Merry Christmas, Happy New Year, and whatever else anyone celebrates in during Holiday Season.

María de la Torre
President and Executive Director

maria.delatorre@meboresearch.org

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Related Posts:

MEBO and Eliapharma TMAU Testing and future research goals

MEBO and Eliapharma TMAU Testing Update 4

INTERNATIONAL TMAU TESTING UPDATE 3

INTERNATIONAL TMAU TESTING UPDATE 2

INTERNATIONAL TMAU TESTING UPDATE

More about TMAU testing through MEBO Research

TMAU Test with Eliapharma through MEBO Research

International TMAU testing in Canada : Special Group Rates

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Trimethylaminuria case study in the Lancet

The British Medical Journal, The Lancet, this month includes a case study of a 45 year old man in Holland who has a severe body odor and was diagnosed with Trimethylaminuria (TMAU).

We do not have access to the full article but we are told he had a phenotype diagnosis with the urine test at the metabolic lab of the university of Neijmegen and Edit : It was originally thought the genetics were done in Heidelberg Germany, but a commenter has informed us it was in fact done : "by Prof Cornelis Jakobs PhD Metabolic Unit, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands".

In January, 2006, a 45-year-old man presented to our department; he complained of a strong objectionable body odour, resembling the aroma of fish, which had a profound influence on his life. He decided to seek help, because of marital problems related to his body odour. His wife noticed that the smell was present in his sweat, urine, semen, and saliva, and it got worse with consumption of certain food products. He had been offered a better job, but declined when he noticed that he had to sit in ...

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61151-8/fulltext

http://www.ncbi.nlm.nih.gov/pubmed/21075259

IRS has received MEBO Research's 501(c)3 Charity Application

I am happy to announce that according to the FedEx Tracking system, the U.S. Internal Revenue Service, E. O. Application Receiving Department has received MEBO Research’s 501(c)3 non-profit (Charity) application. This very long and involved application, IRS Form 1023, was done for MEBO on a pro-bono basis by The Legal Clinic of the College of Law of Florida International University This same Legal Clinic had also filled out the necessary documents to incorporate MEBO Research, Inc. in the State of Florida, on April 21, 2010 as a Not for Profit Organization. It is with profound gratitude that I thank this institution, my Alma Matter, for extending this pro-bono service to us.

According to www.form1023help.com/id4.html, which explains how the IRS Processes Exemption Applications work, the final disposition of the applications received in the fiscal year 2007 were 79% Approvals, 2% Denials, and 19% Others. This article states,

(“Others” includes transfer to National Office, failure to provide additional information when requested, and status granted different from status applied for.)

If the IRS denies your application, they must provide you with a written explanation of the facts, law, and argument upon which their decision is based, as well as an explanation of your appeal rights.

In the very professional manner in which MEBO’s form was filled out by the Legal Clinic, I am very confident that we should not have any problems. My sincere gratitude goes to those persons who gave donations specifically for this purpose to raise the $750 fee required to register MEBO as a Charity in the United States.

The benefits of this status would be that it would put MEBO in a much better position to obtain grants and donations because they would be tax deductable to the donor, and to relieve MEBO from having to pay many taxes as well at the end of each fiscal year. Therefore, we expect a good return on our investment in the long-term.

Updates on this application process will be published on this site.

María de la Torre
President and Executive Director

www.meboresearch.org
maria.delatorre@meboresearch.org

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TMA and Epilepsy, learning disabilities, anxiety, and more

There are two articles in PubMed that link TMAU to seizure activity, anxiety, and learning disabilities. It seems that even though TMAU is not considered to be a serious medical condition, it does seem to wreak havoc with other diseases. In addition to epilepsy, some sufferers who suffer from autoimmune diseases and allergies claim that their odor symptoms seem to trigger their conditions. Much more research is needed in this regard.

Literature reports only two cases affected by trimethylaminuria and epilepsy. We describe a third patient who, from the age of seven, was affected by temporal focal seizures with nocturnal episodes of nausea, vomiting, anxiety and autonomic activation followed by headache...Our patient also showed learning disabilities despite a normal intelligence quotient (IQ), while another described patient had an IQ varying from borderline to mild mental retardation. We discuss the association between trimethylaminuria and epilepsy, and formulate some hypotheses on the relationship between trimethylamine convulsive effect and the anticonvulsive role of levetiracetam.
Epilepsy and trimethylaminuria: A new case report and literature review. Pellicciari A, Posar A, Cremonini MA, Parmeggiani A.Brain Dev. 2010 Oct 20. [Epub ahead of print] PMID: 20970269 [PubMed - as supplied by publisher]

A 16-year-old left-handed male is presented with a history of seizures associated with a fish-like odour and behavioural disturbances thought to be related to trimethylaminuria...The episodes would start with a fish-like odour, followed by seizures occurring in clusters and behavioural disturbance consisting of agitation, mixed affective symptoms, auditory hallucinations and delusions. A urinary assay of trimethylamine (TMA) was elevated, confirming the diagnosis of trimethylaminuria in this patient. He was treated with a choline-restricted diet with resolution of his symptoms.
Trimethylaminuria associated with seizures and behavioural disturbance: a case report. McConnell H, Mitchell SC, Smith RL, Brewster M., Centre for Epilepsy, Maudsley Hospital, London, UK. 1997 Aug 6. PMID: 9304724 [PubMed - indexed for MEDLINE]

A low choline diet isn't the only diet that helps control seizure activity. There is another online article on 3kimt.com about a little boy with epilepsy, not identified as having a TMAU or other odor conditions, who is controlling his seizures with ketogenic diet under the care of Dr. Elain Wirrell, a Pediatric Epileptologist at the Mayo Clinic. Yet Dr. Wirrell associates metabolic conditions as some of the different causes for seizures.

"There are some side effects, it's not for everybody and so there are some different causes for seizures different metabolic conditions which would make it very dangerous to use so we have to exclude those possibilities," said Wirrell.

Our Own Website to book Washington DC Embassy Suite Reservations

THE DULLES AIRPORT EMBASSY SUITES has created a webpage especially for MEBO Research's annual meetup to facilitate our reservations process! On this webpage you can see all the hotel and booking details, such as the special rates offered to MEBO members and guests for our meetup, the applicable Check-in dates, booking deadline, Tour Hotel, Maps, Directions, Amenities, and sites to visit in the area. Most importantly, making reservations for our group rate is only a click away.

This location was recommended by one of MEBO's Board Members, Glenna Gonzalez, Public Relations Director, and she was given a personal tour of the hotel. She was very impressed with it, and so now we have worked a great rate with the hotel Sales Department. We thank Glenna for her time and effort to get this great place for us to hold our meetup.

Room rates include :

• Complimentary daily full breakfast per person
• Complimentary daily 2-hour Manager's Reception, serving alcoholic and non-alcoholic beverages and snacks
• Complimentary Dulles Airport shuttle
• Free self-parking.

Even though the Terms and Conditions state, "Rates published are for single occupancy. An extra person charge per person may apply for 2 or more guests sharing the same guestroom," MEBO's group rate of $89/night are for single, double, triple, and quad occupancy, as stated in the contract I signed with the hotel:

Room	Single Rate	Double Rate	Triple Rate	Quad Rate
Run of House	$89.00	$89.00	$89.00	$89.00

Please read the terms and conditions carefully for information on the multiple taxes imposed on this rate. You can guarantee your room at any time with a credit card, which will not be charged until checkout time after your stay. Inf you wish to cancel your reservation, you would need to do so 24 hours before arrival to avoid cancellation penalties. There is also a fee for early departure.

Embassy Suites Dulles Airport

13341 Woodland Park Drive

Herndon, Virginia 20171

1-703-464-0200

María de la Torre
President and Executive Director

maria.delatorre@meboresearch.org

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Related Posts:

Washington DC 2011: You can book MEBO’s 2nd Annual Meetup

Spring 2011 Meetup in Washington DC

Video Testimonial of Crystal Y

We have posted many videos in this blog, most involving sufferers who tell their story on television networks in the United States and United Kingdom. We have had numerous videos of Arun inviting us or telling us about the various meetups in the UK, and I’ve enjoyed myself creating videos of meetups in the UK and Nashville, TN, US that I’ve attended, as well as beautiful places I’ve visited. But I must say, some of my favorites are the “home made” videos done by sufferers in their own homes with their cam cameras sitting at their computers. Those are relatively unrehearsed or coached, and they come straight from the heart.

Here is a video of a beautiful young lady, Crystal Y from the Serendip Body Odor group, from Bryn Mawr College, who just wants to ‘come out’ to us, and to tell us her story. Crystal told me that she would love for others to see her video and is honored to have the opportunity to inspire someone else. These are her words:

Hi María,

I appreciate the amazing feedback on my video! I absolutely do not mind if you post it,...In fact, I want others to see it. I'm honored to have the opportunity to inspire someone else; if I could inspire just one person in the smallest way, that would mean a great deal.

Thank you again and I look forward to connecting with your community as well.

Sincerely,

Crystal Y

I know everyone will enjoy the experience of meeting Crystal in this video. She says that would love to hear from us too, and she gives us her email address, sweetlady2222@hotmail.com in case anyone would like to write to her.


We have a page in MEBO’s blog called “COMMUNITY INVOLVEMENT,” and I invite everyone to browse through the "COMMUNITY FORUMS AND BLOGS" and to visit some of the various community forums and blogs it lists from around the world of the English speaking communities as well as the "DIVERSE LANGUAGES BODY ODOR FORUMS AND BLOGS". This page also has a section on "BOOKS WRITTEN BY SUFFERERS", including an anthology written by the former MSN Body Odor Support Forum that was closed and we migrated to the new Body Odor Support Forum bought for us by Arun Nagrath. This page also lists "INTERVIEWS WITH EXPERTS" that have so kindly given of their time to explain to us about body odor conditions and their recommendations.

The last but not least section of this page in our MEBO Blog invites sufferers to "MAKE YOUR OWN BODY ODOR/HALITOSIS VIDEO" as Crystal has done. We also have another sufferer who did a 3 Part video that we posted, “Filipino gentleman talks about his TMAU on CNN Ireport website”. We can all see how healing and inspiring their videos can be for many of us.

MEBO’s hope is to bring the whole international community together, to unite in sharing with each other so that we can support each other, and when research opportunities come along, there will be plenty of us to help the scientists help us on a voluntary basis only.

María de la Torre
President and Executive Director

maria.delatorre@meboresearch.org

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Halitosis: could it be more than mere bad breath?

The public and institutional perception of 'halitosis' is that it is strictly a 'localized' problem, so it is good to see a medical paper that discusses the concept of 'bloodborne halitosis', also referred to as alveolar halitosis, where the source of the breath odor is deemed to be coming from the lungs via the circulation. However, the abstract seems to imply that bloodborne halitosis may be a sign of a serious underlying illness, which does not seem to be the case for most of our readers.

The paper is by staff in the Department of Oral Sciences, University of Palermo, Italy.

Quote :

"Halitosis is a generic term used to describe unpleasant odor emanating from the mouth air and breath, independent of the source where the odor substances originate. It affects between 50 and 65% of the population, but despite its frequency, this problem is often unaccepted and declared as taboo. Ninety percent of patients suffering from halitosis have oral causes: a small, but important percentage, of oral malodor cases have an extra-oral etiology, very often falling into the category of "blood-borne halitosis". Several systemic diseases have been found to provoke malodor or to be a cofactor; bad breath may be an early sign of a serious local or systemic condition..."

Abstract : Halitosis: could it be more than mere bad breath?

Interview : Dr John Cashman of HBRI in San Diego

helpful links :
CYP
CYP 3A4
DME's
FMO
FMO3With the interviewee's permission, we have managed to compile a question and answer interview from a recent email dialogue about the enzyme Flavin containing monooxygenase isoform 3 (FMO3) with one of the leading experts in this group of enzymes (as well as expertise in many other human enzymes), Dr John Cashman of the Human Biomolecular Research Institute in San Diego. The dialogue was to try and understand more about FMO3 since sub-normal FMO3 is responsible for genetic trimethylaminuria. Dr Cashman has a long history in TMAU/FMO3 research, especially in the genetic field.
Dr John Cashman medical papers on TMAU/FMO3

We thank Dr Cashman for being so helpful to the TMAU community, and for his long association in research that is directly related to genetic TMAU.

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Is FMO3 one of the most widely used enzymes we have ?
Based on the publications in the literature, I think FMO is underrecognized. It is present in adult liver to a great extent, almost 60% of the amount for the major CYP enzyme (CYP3A4) that does most human drug metabolism currently listed in the literature.

Is there a rule of thumb that we can use to know when something in the diet is likely an FMO3 substrate ? (eg. greenfoods, foods with sulfides, etc) It sounds like almost all vegetables, herbs, spices and proteins potentially.
Yes, FMO prefers smaller nucleophilic compounds: Sulfur-, Nitrogen-, Selenium-, and Phosphorous-containing compounds. But not all that contain these heteratom-containing compounds are nucleophilic as the atoms can be in aromatic rings and non-nucleophilic.

Are all (or many) sulfides, amines, and phosphates FMO3 substrates ?
These substrates need to be nucleophilic. Not all sulfides etc are nucleophilic. Phosphines not phosphates, and organo selenium compounds. But the enzyme substrate binding region has some size requirements or limitations.

Do you expect people with FMO3 deficiency could have problems with FMO3 substrates other than TMA ? (including endogenous)
Yes, I think there could be adverse drug reactions as the amines are not N-oxygenated, for example and are not rapidly cleared. There are many drugs that are amines but not enough research has gone into determining if any of these amine drugs are substrates for FMO. My suspicion is that many more than are currently recognized are substrates for FMO.

Is FMO3 the only likely Drug Metabolizing Enzyme (DME) associated with smells ?
I am not sure about this because other DMEs including CYP metabolize amines, sulfides and phosphines.

Can we survive with zero FMO3 function with no obvious problems apart from TMAU?
I am not sure that the experiment has been done in terms of making a FMO3 knock out mouse and looking at the consequences of this. My suspicion is that FMO3 is involved in some important mammalian developmental function that we don't recognize currently.

CYP3A4 seems to be inhibited by a wide range of chemicals which I presume may be constantly updated. We know that indoles inhibit FMO3. Do you think it is likely that more FMO3 inhibitors that are common in the diet are likely to be discovered?
FMO evolved to metabolize plant-derived materials. This was important early on as evolving mammals needed to protect themselves from all the nucleophilic materials in plants. Yes, I suspect there are a few more nucleophiles that avoided this process but I think most are detoxicated (N-oxides and S-oxides are metabolites). The problem may come in as reductases also evolved to retro reduce N-oxides and S-oxides. These may be more efficient and be the source of the problem. Another important issue is that sometimes FMO produces a reactive metabolite that does not inhibit FMO but leaves the FMO enzyme and inhibits CYP.

Endogenous compounds are compounds created in the systemic circulation. Are there any endogenous compounds that are good FMO substrates ? e.g. hormones or neurotransmitters or blood pressure regulators.
We have published that tyramine and phenylethylamine are FMO substrates. We looked at the other major ones and they do not appear to be substrates: Serotonin, Dopamine, Norepinephrine, Histidine apparently are not substrates for FMO3.

Is FMO present in the gut ?
Yes, FMO is in the gut. I think FMO1 and FMO5 more so than FMO3 but this is in a review with Jun Zhang we published years ago.
see: http://www.ncbi.nlm.nih.gov/pubmed/16402899

Looking at the list of inhibitors for CYP 3A4 on wikipedia (eg citrus, echinacea, milk thistle), It looks as if flavonoids are a particular problem for CYP enzymes? I wonder if these compounds could inhibit FMO3 ?
Probably not. But not sure on this one. Most of the CYP (inhibitors ?) in citrus are polycyclic flavonoids. No nucleophilic atoms are present. So it is unlikely non-nucleophiles are inhibitors. There is a report out there that caffeine is a substrate for FMO3. This is wrong. Not an inhibitor either. No nucleophilic centers. There are a number of azoles (ketoconazole) and imidazoles (cimetidine) that inhibit/alternate substrates for FMO3 but these are from nucleophilic groups in the molecule.

It has been hypothesized that if someone has a bad reaction to a drug it is more likely due to a DME enzyme deficiency rather than an allergy. What are your thoughts on this ?
I am not sure of this one. I think most reported adverse drug-drug interactions (DDIs) occur when there is an excess of a drug compared to normal clearance and reasonable therapeutic levels. There is a DOSE-dependence. Often with allergic reactions, dose is not that important and small concentrations can illicit an immune response. Most DDIs reported are related to liver metabolism.

Pepper is a spice that has anecdotally caused bad reactions such as nightmares.
Pepper inhibits gut metabolism and permits things to be more efficiently taken up through the gut. I dont believe this has been examined as a substrate or inhibitor of FMO.

Could there be an FMO connection with intolerance of garlic ?
Lots of people don’t do very well with garlic including me. My father loved it. There are numerous sulfides in garlic. But this is likely complicated because some of these compounds exist as more complex precursor compounds and intolerance may be related to other enzyme systems.

A lot of people on the forums have as one of their many various odors a smell of burning rubber. Could this be a phosphorous compound ?
I think the compound smelled in burning rubber is a sulfur-compound based.

Quite a few in the group feel they have an allergy to penicillin. If this was rather to do with the DME's, could it be FMO3 deficiency ?
I think penicillin is a direct-acting allergen that is probably normally moped up but if someone doesn’t have adequate protein to protect then it reacts with key proteins that illicit an immune response. That is why it may be idiosyncratic. I don’t think it has much to do with DMEs or metabolic bioactivation. However, reaction to penicillin may indicate a more sensitive immune system.

Is smoking bad for someone with a FMO3 deficiency ?
Nicotine is an FMO3 substrate. It is only N-oxygenated about 5% of a dose but it is a detox pathway. Defective FMO3 will cause individuals to be more susceptible to nicotine. It may be that people with defective FMO3 may be more sensitive to the properties of nicotine.

Would it be impossible to follow a ‘low FMO3 substrate’ diet?
Due to the ubiquitous nature of amines and sulfides in the diet, it may be difficult to have a diet free of FMO3 substrates. However, one can try to avoid choline, for example and this may help a great deal. However, it is important to note that choline is essential in development and child-bearing age women need to consume adequate choline if they are contemplating pregnancy.

What do you think the results of this dissertation imply? http://digitalcommons.library.tmc.edu/dissertations/AAI1450285/
I did not read the dissertation but I did read the Abstract. I agree, more work needs to be done especially the role of non-exon mutations of FMO3.

Many people say they smell of many various smells systemically. We wondered if there is a possible FMO3 connection.
Yes, individuals reporting TMAu symptoms report various smells and this has been confirmed by other experts.

We wondered if the following were good FMO3 substrates ?
hydrogen sulfide: probably not
methanethiol: yes
dimethylsulfide: yes
dimethyldisulfide: yes. I believe it is a very good substrate.
ammonia: probably not
mercaptans: Yes, depending on the structure
Any others you wish to mention : Phosphines.

We wondered if the following things mainly in the diet or endogenously are FMO3 substrates ?
amines in diet
sulfurs in diet
phosphorous in the diet
selenium supplement
FMO3 substrates created endogenously
FMO3 substrates created by the gut flora (aside from trimethylamine)
methyls
It is difficult to answer a broad question like this without some specific examples.

There was a recent paper about FMO3 induction. http://www.ncbi.nlm.nih.gov/pubmed/20570689
Do you think it has any potential as a treatment ?
Not 3-MC. This also induces lots of other things and leads to liver cancer induction. I think induction FMO3 is not the real solution to TMAu. And note, in the report, the functional enzyme activity was not "induced" as much as the RNA.

It’s been suggested that Ataluren may be worth trialling for those with FMO3 nonsense mutations http://www.ptcbio.com/3.1.1_genetic_disorders.aspx. Do you think this is an option for investigation and what percentage with TMAU1 have nonsense mutations ?
Very very few individuals with TMAu in our analyses have nonsense mutations. I don’t think this is worth the risk.

A DME expert suggested ingestion of synthetic FMO3 may be theoretically possible but thought the side effects may make it unfeasible. What do you think of this idea ?
We are looking into this. There are many hurdles in this business. I am not sure about side effects of FMO3.

Is there any other ideas you have as potential treatments ?
I have lots of ideas but no money or time to pursue them.

MEBO RESEARCH STAFF

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MEBO and Eliapharma TMAU Testing and future research goals

Update 5

Each person who tests through MEBO/Eliapharma can feel the pride that comes with being a part of a movement that proactively seeks to find answers and a cure for all types of body odor conditions.

IT is in keeping with MEBO Research's Mission, "to support the scientific and medical communities to perform formal professional research into body odor and halitosis conditions,” that MEBO has chosen Eliapharma Services Inc., to perform phenotype TMAU test (urine test) for our community. As noted in their website, this lab has been involved in Analytical, Bio-analytical, medicinal chemistry, and preclinical and clinical services, for Biotechs, University Research Centers, Institutes, Pharmaceutical Companies, Generic Companies and Hospitals. Consequently, Eliapharma is now in a good position to apply for (and hopefully obtain) research grants from the Canadian National Institutes of Health and/or some of the pharmaceutical companies they have worked with in the past. This process will take time, as much preliminary work would be needed, such as gathering data through testing and establishing a database, initially of TMAU test results and eventually of the various types of body odor conditions, and a great deal of documentation would have to be drafted to support research funding.

Each person who tests through MEBO/Eliapharma can feel the pride that comes with being a part of a movement that proactively seeks to find answers and a cure for all types of body odor conditions. While MEBO and Eliapharma are totally committed to protect the privacy of each person by assigning each person an account number so as never to divulge personal information such as name, address, and telephone or email contact to anyone without prior written authorization if ever needed, we hereby disclose that all test results and answers to voluntary surveys will become part of the database used for future research.

Since Eliapharma is a research lab and our program has research aspirations, the lab can perform TMAU tests and give the results to the person testing without doctor’s order.

Therefore, by signing the agreement and disclosure in the application form, the person testing will be giving his or her expressed written consent for MEBO Research or Eliapharma Services Inc. to divulge only the test results data and voluntary survey information to be shared only with research organizations, such as pharmaceutical companies, university research departments, and any other agency that may have expressed interested in performing in-depth research into TMAU and other causes of unusual and difficult to control body odors.
It is also hoped that those persons testing will also volunteer to fill out the survey created for this purpose. If Eliapharma and this project were not research oriented, we would not be able to perform this TMAU test without a doctor’s orders.

Another reason MEBO has chosen Eliapharma as the lab to work with is because it is the only lab in the Western Hemisphere that is willing to accept specimen from sufferers in Central and South America, as well as from Mexico and other parts of the world.

The TMAU test done through Eliapharma looks for both, Primary and Secondary TMAU, and measures both the TMA levels and the metabolic enzyme function involved in the metabolism of TMA, similar to the way it is done in the United Kingdom. Below is a detailed breakdown of the testing cost:

• $110.00/US : Eliapharma charges only $110 for the analysis of 2 separate urine specimen collections per kit. With an additional $60/US, another specimen may be tested (up to 4 additional samples at $60 each). More than one person can participate per kit.This is one economical way to test the whole family (up to 6 different people). For 6 people, the test charge would be $350 ($110 for 2 plus $60x4 =$350)
• $30.00/US per kit: MEBO charge $30 for the kit supplies, insurance for unforeseen damage to specimens in transit, currency exchange fees, and PayPal fees,
• $10.00/US per kit : to cover the $1,000 investment commitment MEBO Research has made to set up the lab for testing (Eliapharma is investing approximately $2,400).
• SHIPPING COST : Round trip shipping cost depending on place of residence, which includes ground or lowest shipping cost to send the kit from the lab and priority overnight or 2 day shipping, whichever is lower, for the return kit containing the frozen specimen. This shipping cost will also include any additional fuel surcharge fees or other fees established by FedEx.

Anyone interested in participating in this TMAU phenotype testing and contributing to future research, while we commit to protecting the privacy of your identity, please express interest with an email to, tmautest@meboresearch.org

SEE COMMENTS BELOW FOR Q & A

María de la Torre
President and Executive Director

maria.delatorre@meboresearch.org

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Related Posts:

MEBO and Eliapharma TMAU Testing Update 4

INTERNATIONAL TMAU TESTING UPDATE 3

INTERNATIONAL TMAU TESTING UPDATE 2

INTERNATIONAL TMAU TESTING UPDATE

More about TMAU testing through MEBO Research

TMAU Test with Eliapharma through MEBO Research

International TMAU testing in Canada : Special Group Rates

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MEBO and Eliapharma TMAU Testing Update 4

The President and CEO of Eliapharma Services Inc., Samir Nassr, M.Sc., informs us that the Import/Export Permit has not yet arrived at his office, even though the Canadian authorities had informed him that he would receive it by December 2nd. Consequently, we will not be able to begin mailing the kits to the 35 people on the waitlist to initiate our International Testing Program in Canada until we receive it. As soon as we do, it will be posted in this blog, and each person on the waitlist will receive an email inviting them to fill out the application.

I apologize for this delay, and I thank you for your very much appreciated patience. Sometimes government transactions take longer than originally planned.


María de la Torre
President and Executive Director

maria.delatorre@meboresearch.org

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Related Posts:

MEBO and Eliapharma TMAU Testing and future research goals

INTERNATIONAL TMAU TESTING UPDATE 3

INTERNATIONAL TMAU TESTING UPDATE 2

INTERNATIONAL TMAU TESTING UPDATE

More about TMAU testing through MEBO Research

TMAU Test with Eliapharma through MEBO Research

International TMAU testing in Canada : Special Group Rates

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