8th November Special Conference Call : Featuring Cheryl Marshall : Founder of the NORD TMAU Fund and recently featured on Mystery Diagnosis TMAU story

Please join us on a Special Conference Call featuring our very own, Cheryl Marshall to be held on Sunday, November 8, 2009 at 2:00pm. As we all know, Cheryl’s story about Trimethylaminuria was recently told in a Mystery Diagnosis episode this past spring (2009). Cheryl’s presentation and Q&A session will begin at 3:00pm. She will be sharing her experiences in making this documentary, living with and managing her TMAU, and she will tell us all about the NORD TMAU Fund as well. Please bring all your questions that you may want to raise with Cheryl.

Cheryl was responsible for the founding of the NORD TMAU Fund, and recently with a few other sufferers she set up a special fundraising website for the NORD TMAU Fund; rrr-tmau.com , which she will be talking about.

Cheryl, thank you for being there for us, for coming forward and telling the world about TMAU, and for being the brave and caring person that you are!

Special Conference Call
Sunday, 8 NOV 09
2:00pm and Cheryl's presentation begins at 3:00pm

For USA-based : (712) 432 1620
then type the access code on your phone keypad: 391629#
Non USA : prefix above with 001 but check to see if it is free with your supplier.

Free USA-based phone conferences (if you have a long distance call plan. Otherwise you will be charged as a long-distance call)

WE’LL SEE YOU THERE!

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related links:
phoning the TMAU conference call cheaply from overseas

Expert overseeing MEBO Research Studies

we are most grateful to Dr. Irene Gabashvili, PhD, for overseeing MeBO Research's exploratory trials. She brings with her years of experience in biomedical industry and academia. Dr. Irene is the founder of Aurametrix and an y Adjunct Professor of Bioinformatics and Biotechnology at San José State University.

Throughout her career, Dr. Gabashvili has been interested in the molecular, cellular, and physiological mechanisms of health and disease. She developed models and data analysis approaches and experimentally studied physics of microbial infection, chemistry of light and radiation effects on living matter, plant enzymes, structural basis of antibiotic resistance, human pathologies dependent on variation in mitochondrial genes, development of sensory apparatus and aging, and inheritance and environmental factors contributing to the development of diseases.

Dr. Gabashvili was overseeing exploratory trials and data mining studies in the past, working with medical doctors and supervising MD students. For example, she studied analysis of blood biomarkers to determine patterns of longevity at the Center of Genetic Ecology. She worked in microbiology, molecular biology, biochemistry and biophysics labs and was utilizing state-of-the-art techniques and instrumentation to characterize macro- and micro-molecules causing or protecting from disease. She continues to collaborate with experimental labs, in particular employing novel chromatographic and mass spectrometry approaches to identify disease biomarkers.

Dr. Gabashvili has developed software tools and IT infrastructure to support research and clinical processes. She worked with and for Hewlett Packard, Merck, Pfizer, Johnson & Johnson, Novartis, etc. Her academic partnerships include renowned scientists and clinicians from Stanford and Harvard Universities.

Dr. Gabashvili demonstrated a concerted interest in applying her wealth of knowledge to MeBO's research aims for the betterment of our community. She is especially interested in clinical nutrition and the complex relationship between the human immune system with trillions of microbes populating human beings. You can contact her directly by e-mailing to Irene at Aurametrix.com.

Irene Gabashvili, PhD

Scientific Director, MEBO Research

Founder of Aurametrix

irene@aurametrix.com & irene.gabashvili@meboresearch.org

http://aurametrix.com

http://www.linkedin.com/in/igabashvili

http://sites.google.com/site/irenegabashvili

http://www.biology.sjsu.edu/facultystaff/gabashvili.aspx

See Slideshow presentation "Microbes and Us"
Alphabetical List of Pathogenic Bacteria

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María de la Torre
President and Executive Director

www.meboresearch.org
maria.delatorre@meboresearch.org
MEBO's Blog (English)
El Blog de MEBO (español)

Translated in Spanish by:
Natalia
Autora del Blog

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First tester's results in the MeBO-Biolab Gut Dysbiosis in systemic body odor and halitosis study

The first volunteer for the MeBO-Biolab gut dysbiosis study has completed his tests. The study is intended to look at various aspects of 'gut dysbiosis' in relation to metabolic body odors and halitosis, to see if there are any patterns.

These were the results of the first tester :

Gender : Male, 30s
Odor type: Had a fecal halitosis problem for many years and feels it is systemic based

Tests done:

• Gut fermentation test : normal (according to Biolab)
• Indicans : normal
• D-lactate blood test : normal
• Gut permeability : some malabsorption of the smaller sized molecules. Did not have 'leaky gut'

The tests were chosen to examine various aspects of 'gut dysbiosis' (though not all). The gut fermentation test is regarded as being reliable for testing candida overgrowth in the small intestine (using ethanol as the marker). It also tests for other alcohols and fatty acids associated with bacterial dysbiosis. The gut permeability test examines the persons absorption ability, as well as testing for 'leaky gut' (hyper-permeability).The d-lactate test was chosen because a recent chronic fatigue paper suggested that d-lactate acidosis may be implicated in many chronic fatigue cases. It is also hypothesized that a bi-product of this could be hydrogen sulfide production. The indicans test is an inexpensive test associated with protein putrefaction by bacteria.

The first testers results seemed to be mostly normal apart from some 'hypo permeability', which is decreased absorption of some smaller sized molecules. At the moment, we could not suggest what this could be, except a slight malabsorption issue. This is the opposite of 'leaky gut', in which case, molecules would be too large get through the gut semi-permeable wall.

The 2nd volunteer is now testing, the 3rd will start soon, and others interested are welcomed to volunteer if they wish.

The expert that is kindly helping us, Dr. Irene Gabashvili, has sent these comments about the results to the tester. Each tester will also receive such comments from her based on their test results.

As you know, your results are opposite of a leaky gut - decreased and not increased permeability as compared to healthy individuals. Your intestinal permeability is not decreased too much though, so these are just a few pointers:

Lining of the intestines has a few relatively large pores and many small pores letting small molecules to pass through. Leaky gut means more large holes in the gut that let larger molecules to enter the blood stream before they are broken down into "edible pieces". In some other conditions, the number of small pores and entire intestinal surface area gets reduced - tightening the gut and slowing down the normal flow, decreasing intestinal permeability and causing malabsorption.

Sometimes decreased permeability is because of vegetarian diet, fasting or smoking.

I believe, MEBO community will benefit from better understanding of
diets and symptoms - I hope to develop an anonymous web tool for easy
logging and interpreting the data. Any suggestions would be
appreciated.

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Donate to MeBO Research

What MeBO is doing

About privacy:
see Donate page

Currently raised:
173.50 GBP = 275.84 USD
13OCT09

MeBO is continuing with this line of study, and anyone is welcome to participate. Unfortunately, each participant would need to pay for the tests themselves, which in total would be £146 if all tests are chosen by the tester. MeBO will collate the non-personal data and look for a pattern from amongst all testers under the direction of Dr. Irene Gabashvili.

MeBO hopes to continue such tests and aspires to become a charity. As a charity, MeBO can then pursue grants and endowments in order to carry out large-scale international studies. Anyone wishing to donate to MeBO's aims to further support this and other studies could do so using the PayPal button in this post and in MeBO's website. Your support would be greatly appreciated by anyone suffering from a body odor condition who is looking for answers.

Anyone who would like to be part of the study could do so by filling out the MeBO-Biolab gut dysbiosis in body odor or halitosis study form-REVISED.
Or you can contact Maria by email at meboresearch@gmail.com.

Researchers compare the portable sulphur monitors Halimeter and OralChroma in halitosis cases

A team of researchers from Belgium have recently published a research paper on the use of the halimeter (by Interscan) and oralchroma (by abilit) as halitosis measuring devices on a large number of people claiming to have halitosis. The department they are from has a background in halitosis research.

2009 paper : Clinical reliability of non-organoleptic oral malodour measurements

Vandekerckhove B, Van den Velde S, De Smit M, Dadamio J, Teughels W, Van Tornout M, Quirynen M.

Department of Periodontology, Catholic University of Leuven, Leuven, Belgium.

Aim: Measurement of volatile sulphur compounds (VSC) by portable sulphur monitors (Halimeter((R)), OralChroma()) is a common practice for diagnosis of oral malodour. In this study, the clinical value of these devices was examined. Materials and Methods: Two hundred and eighty patients with bad breath complaints attending a halitosis consultation were enrolled. Organoleptic scores were given by a trained and calibrated judge, before measurement of the VSC levels (Halimeter((R)), OralChroma()), to avoid any bias. Results: Significant correlations were found between the organoleptic assessment, the Halimeter((R)), and the OralChroma() (R=0.74 for organoleptic versus Halimeter((R)); 0.66 for organoleptic versus OralChroma(); 0.63 for Halimeter((R))versus OralChroma()). The sensitivity and specificity (with regard to the organoleptic score) to detect patients with/without oral malodour for the Halimeter((R)) were 63% and 98%, respectively, and for the OralChroma() 69% and 100% when using the cutoffs suggested by the manufacturer. By lowering these values, sensitivity could be improved without a significant decrease in specificity (both devices). Conclusions: We concluded that the measurement of the VSC levels can be used as an adjunct to the organoleptic assessment. Thresholds should be revisited in order to improve their clinical utility. These devices can prove the absence of malodour in case of pseudo-halitosis.

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Related links :
Van den Velde pubmed papers

A list of dental clinics with the 'halimeter' for halitosis testing

The 2 types of 'gold standard clinical setting' tests (seemingly according to the dental industry) for halitosis seem to currently be either use of the 'oralchroma' machine, or the 'halimeter'. A recent post demonstrated the oralchroma in use in a dental setting. The halimeter was probably the first such machines on the market, and was the original popular choice for dentists wishing to give patients the option of testing for halitosis in a dental practice. The general 'vibe' on the halitosis forums is that there doesn't seem much confidence in dentists for their condition, but for those wishing to at least be tested with cush a device, the halimeter website does at least have a list of dental clinics which own a halimeter. Presumably this is just a small selection of all such clinics who have a halimeter. At the moment, it is very unlikely that a dentist is aware of halitosis via metabolic odors, although the halimeter is set to detect certain sulfides.

List of international dental clinics that have a halimeter (from the halimeter website)

Bloodborne body odor & halitosis : asparagus urine test experiment

It has been mentioned here before, that asparagus is known to make some people's urine smelly, but others not. However it is not widely known that there seems to be a 3rd category where the person is unable to smell smelly asparagus urine. Since it is a 'trivial' problem, probably not enough research has went into finding out all the categories and the reasons. But given the compounds thought likely to cause 'asparagusuria' (sulfides etc), it was thought it may be interesting to find out what the 'pattern' is amongst systemic body odor and halitosis readers may be. For instance, it may turn out to be a way of telling whether people are 'FMO3-vulnerable' or not. Or it may not.

Research into 'asparagusuria' has been very limited, and the few papers done can give conflicting outcomes. For the purpose of this post, it will be assumed that the work of Mitchell is the most convincing, since he has done the most extensive research.
Mitchell 2001 summary about asparagusuria
1987 study : Odorous urine following asparagus ingestion in man.

It appears that people may fall into the following categories :

excretor (of smelly asparagus urine) or non-excretor
and
perceiver (can smell smelly asparagus urine) or non-perceiver

So there are 4 categories people can fit into. For example, someone can have smelly asparagus urine and not perceive it, while someone else can have non-smelly urine and can perceive smelly urine. The excretion part is about whether the person has unmetabolized smelly asparagus compounds in their urine. The 'perceiver' part is about the persons abilty to smell such compounds in urine. Of a study Mitchell was involved in in 1987, of the 800 volunteers, about 43% were 'excretors', and a much smaller amount excretors of very 'potent' smelling urine.

Since smelly compounds are involved, it was thought it may be worth doing a 'snap' poll of our own urine after asparagus consumption, especially since many cannot smell themselves (non-perceivers). A poll is also set up for family/partners as an anecdotal experiment, although the whole experient has the possiblity of 'non-perceiver' over it, since we don't know now for sure if we couldn't smell it or it didn't smell. Not unless you get a known 'perceiver' to smell it !

And so, onto the rules of the study
Asparagus urine test :
eat at least 5 sticks of asparagus (in a meal will do)
sniff urine over the next 12 hours. Especially the next 'batch' of urine after asparagus consumption.

The polls can be read below

Bloodborne body odor : If someone else smelt your urine, could they smell anything ?

Bloodborne body odor : Did your urine smell after asparagus consumption ?

Bloodborne halitosis : If someone else smelt your urine, could they smell anything ?

Bloodborne halitosis : Did your urine smell after asparagus consumption ?

Australian Trimethylaminuria Foundation now has a TMAU store for Australians

The Australian Trimethylaminuria Foundation is continuing it's aim of finding ways to raise funds for Dr John Christodolou's TMAU research proposal. As well as a TMAU store for the USA, it also now has a store for Australia. By clicking through the links and purchasing whatever you want, the ATF will get a % of the purchase. It's a good way of raising money within the community, for the purpose of research. and the best bit is that you are buying things you would want anyway.

Bluesky announced the Australian TMAU store in the ATF yahoo forum. Here is the text :

Hello Australian members,

Have you heard of the TMAU Store yet? At no cost to you, you can support the Australian Trimethylaminuria Foundation simply by "clicking through" the store of links (make sure you click the link off the store, first), and then buying online as you normally would. A percentage, usually about 10-15% of the sale price goes to the ATF.

The products and stores listed are not limited to those for Body Odor, and there is even a Shop by Store page:
http://www.tmaustore.com/shopbybrand.php

However, the TMAU store is US-vendor specific-- or you would have to use "International shipping" (which can take a while to arrive).

Now there is also an Australian version of the store at:
http://tmaustore.com/australia.php

New vendors on this page include AUS/NZ based businesses such as:

Expedia.com.au
Healthstore.co.nz
Discount Vitamin Express
Cool Gifts (AU)
Apple AU
Apex Rent A Car Australia
Circuit Central
Eight Hotels booking (Diamant Hotel Sydney and Canberra, Kirketon Hotel Sydney, Hotel Altamont Sydney, Pensione Hotel Sydney, Pensione Hotel Melbourne, Cosmopolitan Hotel Melbourne)
Hotel.com.au
CheaperThanHotels (last minute deals)
...

there are a bunch more for Travel, Insurance, Vitamins, Baby, Pets, Auto etc.
You can still shop through the main "US-based" TMAU Store ( http://www.tmaustore.com ) and choose International shipping, most of the stores there provide that option.

Blue Sky

Reminiscent of the Thames Festival, BO & Halitosis Meet-Up 2009

It’s been one month already since our Thames Festival BO & Halitosis Meet-Up 2009, and I’m still reminiscent of each and every memorable experience I had there. I would like to share some of these experiences with you in this video. I hope you enjoy it as much as I do.

María

TMAU odor-management protocol - 'British style'

This protocol was shared in the 2009 Thames Festival BO & halitosis meet-up by one of the sufferers to show what has worked for her and others. It’s a list of effective odor management measures derived from the NIH TMAU odor-management protocol, Treatment of Manifestations of the Gene Reviews article on Trimethylaminuria (a research funded by the National Institute of Health, from discussions in the blog and boards, from the USDA Database for the Choline Content of Common Foods, Release Two (2008), and from a great deal of trial and error adapted to the British cuisine, lifestyle, and supplements/cleansers found in Britain.

Some Low Choline Cooking


Check the USDA choline content and try and stick to about 200 units a day
[NOTE: “In 1998, the Food and Nutrition Board of the Institute of Medicine established dietary recommendations for choline intake, estimating an Adequate Intake (AI) at 550 mg per day for men and 425 mg per day for women.” This AI is handled well by persons with normal FMO3 levels. Nonetheless, sufferers should consume only as much as tolerated for odor-management while focusing attention on better health. See additional posts in this blog about the important developmental role of choline. Pregnant and lactating women should not decrease their choline intake for proper fetal development.]


*Most importantly:
Look out for the additives - soya lecithin, phosphates, ammonia, pectin, E numbers if you're buying shop bought stuff - also avoid anything with yeast if possible!*


For cooking - dairy stuff, fresh or fried herbs (never garlic or onions!), balsamic vinegar (but some of them have ammonia so check the label) and cheap white vinegar, fresh lemon juice, wine, tinned tomatoes or certain brands of pasta sauce (Lloyd Grossman brand has no additives)

Most “normal” dishes can be adapted by just omitting the onions and garlic. Instead, make sure you use a good coarse salt and pepper along with small amounts of fresh herbs – this can replace the taste.

Use probiotic yoghurt mixed with cream or cream cheese in sauces to replace gravy


Foods:


Staple Ingredients for cooking:

Plain roast chicken, non smoked pork or bacon and pork sausages (cheaper ones are best but check the label)
Dried non wholewheat pasta or white rice
Porridge oats
French bread, pita bread, (check the label for soya), white crusty rolls
Any full fat dairy - butter, cream cheese, mozzarella, fresh cream, sour cream, creme fraiche, tzatzikki (make sure it doesn’t have mayo in it), probiotic yoghurt, olive oil
Pears, berries, citrus fruits
Tomatoes, courgettes, mushrooms, peppers, sweet potatoes, potatoes, lettuce,
Oven chips (but just the ones with potatoes and oil on the label)
Egg whites
Co-op chicken tikka is mild, nan bread (but not with garlic)
Pizza - the cheaper ones have more additives so check the ingredients
Honey, home made jam or marmalade (not shop bought as it contains pectin)


Sweets
Shortbread (certain brands - organic usually doesn’t have soya) and meringues and some organic biscuits - but check the ingredients for soya or ammonia - not Marks and Spencers tho.
Sainsbury’s Taste the Difference Belgian Dark chocolate and Waitrose Bovetti Milk Chocolate!! Jelly Babies - but not the red ones as they have beetroot in them.
Plain crisps or salt and vinegar ones but check the label for additives
Plain tortilla chips
Home made caramel sauce
Rice crispy cakes
Apple pie
Apple or pear crumble
Tablet
Fudge
Flapjacks
Fruit Jelly
Rice pudding
Yoghurt ice or sorbet
Egg free sponge
Yoghurt


Drinks:
Tea
Lemonade (but check the label for phosphates)
Soda water
Fruit juice or smoothies - any with citrus or berries but not apple or banana
Wine
Spirits which are not grain based are ok
Hot chocolate made with milk and melted soya lecithin free chocolate


Some Main Courses


Roast chicken
Roast Pork
Pasta
Rice
Curries - make without using onions or garlic or chillies
Thai Chicken “Curry” – make without using onions or garlic or chillies
Sweet potatoes – mash or wedges
Roasted vegetables
Salads
Pizza
Nachos

Sauces for pasta or rice
Tomatoes and courgettes, mushrooms or peppers
Chicken or turkey or chicken or turkey mince
Tomato passata or juice
Fresh cherry or plum tomatoes with basil

Iskander:
Fry turkey mince until brown
Add the mushrooms, tomatoes and a little tomato juice
Add seasoning
Spoon into a casserole dish and top with Turkish bread and natural yoghurt
Top with fresh herbs
Bake until cooked

Risotto
Blanch cubes of sweet potato
Fry in a spoonful of olive oil and a little butter with fresh parsley and seasoning
Add risotto rice and stir
Add any of the following: chicken, red pepper, courgette
Keep adding stock cooked (and a little white wine) slowly about a cup at a time until it is absorbed and until rice is cooked

Easy Tzatziki
Mix together:
• Half a large tub of Probiotic yoghurt
• Finely chopped fresh mint
• Half a peeled and finely cubed cucumber
(This tastes better the second day as the flavour soaks in


Soups

Homemade stock – this is very versatile and can be used for soups, risottos, stews and can be frozen into smaller portions for later use:

Leftover roast chicken
2 x carrots (unpeeled) – cut into large chunks
Half a red pepper – remove sides and cut into large pieces
Half a lemon cut into large pieces
Fresh parsley
2 x bay leaves
Salt and pepper

Fry the carrots, red pepper and seasoning in butter until brown then add the other ingredients, cover with water and simmer for 1 hour

You can use this stock to make the following soups:

Carrot and coriander
Sweet potato and carrot
Tomato and red pepper


Breakfasts


Full English – but without the egg yolk
Smoothies with probiotic yoghurt
Any fruit – except apples and bananas with pro yoghurt
Porridge oats with milk
Brose – pinhead oatmeal microwaved with water and butter
Egg white omelette or scrambled
Turkey bacon or unsmoked back bacon, tomatoes, mushrooms, egg white fried
Pork sausages (check the brand for soya or beef casings)
French toast – beat and egg white and fry thin slices of crusty white bread


Washing stuff:

Washing powder - either Ecover or Fairy non bio. I also have a garden spray filled with
white vinegar which I spray things with before washing them

Anything with ph balanced on the label and:

Sanex Natur Protect or dove roll on deodorant
Johnson's baby shampoo and their bubble bath - just the ones in the blue or white bottles
Simple conditioner
Dove soap or Nivea
Johnson's or Morrisons own brand Baby Lotion or Simple moisturiser
Some Netrogena products
Hypo-allergenic make up
Imperial Leather do 2 or 3 bubble baths that are ph balanced
L'Oreal Perfect 11 dye - has no amnonia


Medications:


Boots own make Digestive Health Probiotic and Prebiotic tablets (or any strong probiotics -
but not Holland and Barret ones as they contain pectin) along with probiotic drinks - 3/4 a
day but I stop the probiotics when I'm taking the antibiotics (Metronizadole for about a
week every 4/5 weeks) as they cancel each other out

One in the morning and one at night


2 spoonfuls of Lactulose twice a week


Oxytarm from http://www.oxytarm.co.uk/

One in the morning and one at night



Bodymint from:

http://www.victoriahealth.com/

About 3 in the morning and 2 at night

(Bodymint is pure copper chlorophyllin and it's the highest content available in tablet
form. I sometimes alternate it with charcoal tablets but don't take together as apparently
the charcoal stops the CC from working)



Vegetarian Omega 3 With Flaxseed Oil, Multivitamins, 90 capsules from:

http://www.omega4.co.uk/category/vegetarian+omega3.html

One every morning

It's important to keep in mind that some of the people in the meet-up were saying that they have adverse reactions (odor) to foods high in sugar and/or to dairy products, and that choline foods don't seem to be their particular source of odor. The attached protocol’s diet is choline based, thus inherently addressing protein deficient metabolism as well, so it may not be the answer for everyone.

Another topic of discussion during this year's meet-up was Arun and another medical professional (also a sufferer) who attended, explaining to us that there may be various odor producing sources in sufferers. This diet addresses two of them, dysbiosis (or gut micro-ecology imbalance) and the deficient metabolic enzyme or enzymes. One may also want to see the following keywords on this blog for additional information: dysbiosis, microflora, nutrition, probiotics and prebiotics, skin pH, supplements, and vitamins.

Please be patient, as it takes a couple of months for all the smelly toxins to leave your body. Just think how long it took to build them up in your blood and tissue, possibly years? Rest assured that your body will try to eliminate them, especially when it detects that you are no longer giving it more and more of the same compounds it cannot metabolize. In fact, as your body attempts to secrete these volatile compounds through your sweat, breath, urine, vaginal discharge, and feces, you may be even smellier at first when attempting any odor-management protocol, and then eventually, you will find that it begins to diminish slowly but surely.

Please do give us some feedback after a month or two letting us know how it went for you, but please do so only if you did follow this protocol very strictly. If not, then you would only be confusing the results. I hope some of you try it and let us know how it works for you.

NOTE: Bear in mind that you have to stick to the treatment for a while before you see results because it takes time to get all the volatile compounds out of your system.

Genetests.org page on Trimethylaminuria
Rarediseases.info.nih.gov: What treatment is available for trimethylaminuria?

Our thanks goes to the person who has shared this information with us!

Our 600th post : Blog index

This our 600th post in this blog, which was inaugurated on May 26, 2008, will attempt to give a brief index of the various body odor topics addressed this past year and a half. We hope this facilitates access to the desired subject matter.

Systemic Body Odor Conditions :

metabolic enzymes

• 2001 FMO Paper : Study on Human FMO1 and FMO3 development. FMO1 the main hepatic form before birth. FMO3 after birth.
• Paper: Transient trimethylaminuria in childhood, not because of poor enzyme function : 1998 Paper
• Neonatal with a cabbage smell: and the background of how many 'lesser' health problems are 'discovered'
• The phase 1/phase 2 biotransformation enzymes

FMOs

• 2008 Dr Cashman paper: Role of flavin-containing monooxygenase in drug development
• 2006 paper : FMO3 'in action'
• FMO3 paper hints at 25% possibly with FMO3 issues in a trial
• CYP450 enzymes explanation, from a 'drug metabolism' viewpoint

xenobiotics

• Xenobiotic metabolism enzymes : an attempt at an explanation
• Drug metabolizing enzymes : FMO3 is one such enzyme
• Environmental Impacts on Enzymes involved in metabolism

Trimethylaminuria (TMAU)

• TMAU papers
• TMAU references
• Mystery diagnosis episode about Trimethylaminuria featuring Cheryl Marshall and Dr Paul Fennessey

Halitosis: alveolar breath odor

Possible Systemic or Localized Body Odor Conditions :

hyperhidrosis, bromhidrosis, foot odor, oral sourced halitosis

• 2009 paper on underarm body odor : Acid odor precursors in axillary secretions

Vaginal odor

• Non-infectious and infectious causes of vaginal odor
• Trimethylaminuria: A Noninfectious Cause of Vaginal Odor
• Dr Jelovsek explains Vulvar and Perineal Odor

Gut Dysbiosis :

• Could leaky gut be a factor in Fecal Body Odor ?

• Leaky gut - Liz Lipski booklet

• Bacterial Dysbiosis

• Part 1 and Part 2 of interview with Cass Nelson-Dooley of Metametrix includes discussion on short chain fatty acids (SCFAs) and bacteria

• Video: presentation of Metametrix GIfx stool test by Richard S Lord

Testing :

• TMAU Testing International

• Detoxigenomics dna test by Genova Diagnostic: tests many detox enzymes but not FMO3

Breath Analysis posts

• Gas Chromotography

• Mass Spectrometry

Volatile Organic Compounds (VOCs)

• Sulfur and hydrogen sulfide (smells of rotten egg)

• Methanogens versus the sulfate-reducers in the colon

• 1999 Research paper on hydrogen sulfide and methanethiol in the cecal mucosa (Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa.)

• Hypothesis : what would a thorough examination of a fecal body odor sufferers system look like ?

• Research into a breath test for testing for Volatile Organic Compounds associated with serious illnesses.

Microorganisms in body odor :

• TMA and hydrogen sulfide odor-producing bacteria in the gut and or vagina

• D-lactate acidosis in chronic fatigue syndrome

• Shewanella baltica and other TMA producing bacteria in the gut

• Metametrix Methodology: Polymerase Chain Reaction (PCR)/ DNA microbial testing

• Interview with Cass Nelson-Dooley of Metametrix : Part 1 (TMA-producing bacteria)

• aerobic and anaerobic bacteria, including gardnerella, corynebacteria, shawanella

• yeast and molds, including candida/candidiasis or bacterial

• Vaginosis

Gut Dysbiosis :

• About the leaky gut test (intestinal permeability test)

• Leaky gut (intestinal permeability) urine test can be bought online for around $90

• Leaky gut - Liz Lipski booklet

• Could leaky gut be a factor in Fecal Body Odor ?

• Leaky Gut Syndrome

• “Leaky gut is often involved in cases of dysbiosis…” Cass Nelson-Dooley, Clinician, Metametrix

• Video: presentation of Metametrix GIfx stool test by Richard S Lord, Director, Department of Science and Education, Metametrix Clinical Laboratory

• Dysbiosis : Scientists find a bacteria that may be important in Crohn's disease

• Metametrix slideshow of case study of patient with dysbiosis and leaky gut

Gut fermentation : Clinical gut candidiasis tests

Metabolic enzymes

DNA/Genetics

• Genes for dummies: a simple video guide (4 parts)

• 2008 dissertation paper on TMAU DNA : 8 out of 12 had no (known) mutations

Odor Management :

• An odor-reducing management protocol discussed in the Thames Festival meet-up Parts 1 & 2

• Treatment of Manifestations of the Gene Reviews article on Trimethylaminuria

• Three main protocols of TMAU diet

• The 4 “R” Protocol for Intestinal Health from the GI Effects Interpretive Guide: Remove, Replace, Reinoculate, Repair.

Enzyme replacement theory :

• Hypothesis: genetically modified probiotic for trimethylaminuria

• Genetically engineered bacteria : one possible treatment for TMAU

Prebiotics and probiotics :

Prebiotics

• A retired gastroenterologist's view on prebiotics and the gut microflora

• Cass’s views on prebiotics

Probiotics

• The different types of probiotics

• Probiotics: Metabolic interactions in the gut

• Probiotics: local civilians and special forces ?

• The Barron Report: The Probiotic Miracle

• Video : introduction to probiotics

Flagyl and Nystatin for fecal body odor ?

Antibiotics

Could PTC124 help with primary trimethylaminuria due to a nonsense mutation ?

TMA and hydrogen sulfide odor-producing bacteria in the gut and or vagina

Interview with experts

Research Efforts

• MEBO Research,non-profit organization, projects

• Australian Trimethylaminuria Foundation (ATF), Trimethylaminuria research proposal by Dr John Christodoulou

• NORD TMAU Fund

Orafresh Clinics treat halitosis seriously

Many halitosis sufferers feel that their halitosis is a systemic-sourced problem (i.e. exiting the circulation via the lungs), and could be considered currently ignored by the medical system. However, there are some clinics that take halitosis seriously, although it must be deemed that they will think of it as purely an oral problem. One such clinic is the Orafresh Clinic in Canada (formerly the Freshbreath Clinic), which both rigorously test for and treat oral halitosis (to their specifications). The Orafresh Clinics are now also branching out across North America and elsewhere. It seems that part of their diagnosis strategy is to use the oralchroma gas chromatograph device, which is one of the two best known 'gold standard halitosis checkers' for dentists (the other being the halimeter). It's thought that the Orafresh Clinic also allows TMAU testing, sending the sample to McGill University Health Center in Montreal.

Below are 2 of their youtube videos about how they deal with halitosis at an Orafresh Breath Clinic:

Introducing the rrr-tmau.org fundraising website for the NORD TMAU Fund

Current total : $6350
Target : $30000

Cheryl Marshall, who got NORD to start a TMAU Fund, has teamed up with a few others to come up with a website to encourage fundraising for the NORD TMAU Fund. $6350 has been raised already, and with an online presence it's hoped the $30000 target is achieved quicker. Thanks to Cheryl and the team, and also to all donators. This is your chance to make research happen.

Message from Cheryl on the yahoo TMAU forum

Hello All

We are pleased to announce the launch of an exciting new fund raising campaign to for the NORD Research Fund.

The RESEARCHING FOR RESEARCH RESOURCES CHALLENGE is aimed at raising as much funds as we can.

Several people have pledged various amounts and we invite everyone to pledge what they can-do not feel that you have to give a certain amount-it is what you are able to do.

This challenge requires us to reach out to our family, friends, co-workers - let them know that with their help we will be able to find a cure for TMAU.

Let us commit to making a difference as we go forward with this new exciting challenge. I invite everyone to visit our new Fund raising site: www.rrr-tmau.org

From this site you will be able to track our progress, download our solicitation letter and read inspirational stories of those who are giving to our effort as we Reach for our Research Resources.

Together we can get it done !!

Thanks

Cheryl

How the NORD donation page would look when donating online. You could also notify rrr-tmau.org of your contribution (anonymously or not) so that they can update the amount on their website.

Watch Cheryl in 'Mystery Diagnosis' TMAU episode