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body odor/halitosis : what is your state of occupation ?

Upcoming get-togethers

Feb 5th 2pm : Arun's Northampton meetup
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Cheryl Fields : Montgomery Alabama

Let us know if you want a meetup listed

MEBO Community Outreach Program

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Book uplifting seminars for free.

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email: cheryl.fields@meboresearch.org

EXPERT INTERVIEWS AND PRESENTATIONS

Interview with Nigel Manning

Interview with Dr. Robin Lachmann

tmau.org.uk interview with Dr Robin Lachmann

Interview with Dr. John Cashman

Interview with Cass Nelson-Dooley of Metametrix

Slide Presentation by Dr. Irene Gabashvili

Slideshow Presentation by Professor Elizabeth Shephard TMAU/FMO3 Slideshow Presentation"

About MEBO's Founder and Executive Director

mebo body odor halitotsis
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maria@meboresearch.org

TMAU urine test : what was your result indicative of ?

Send in your original pics and music

Calling all creative peopleWe would like original pics and music for posts and any videos we make. Feel free to send them (non-copyrighted) to
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What do you think are your health complaints of the list below ? (tick one or more)

Blog Archive

NORD TMAU GRANT (one award),
funded by patient group, Trimethylaminuria Foundation,
was awarded to recipient announcement:
Danielle R. Reed, PhD/ George Preti, PhD
Monell Chemical Senses Center
University City Science Center
Philadelphia, PA
“Revisiting TMAU Through Exome Sequencing”
Join the International Body Odor & Halitosis Skype group
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body odor petition
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Tuesday, June 30, 2009

New TMAU support website in the UK

Poster "big vern" recently posted on the curezone TMAU forum that he has started a UK-based TMAU website. Although it is UK orientated, TMAU is a universal problem and so will be one to save in your favorites/bookmarks. It also has a forum that anyone can join.

The site is support-group orientated, and as it says :

Bringing together people who have Trimethylaminuria , their families, friends and healthcare professionals in a positive, caring and supportive environment.
body odor ukhttp://www.tmau.org.uk/

It also has a TMAU forum

It's good to see so many metabolic body odor websites now making an appearance on the internet

Sunday, June 28, 2009

Upcoming events discussed in our Conference Calls


In today's conference call, we talked about:

1. Systemic hyperhidrosis and bromhidrosis: Compensatory sweating and odor after surgery affirms that the cause of this condition is of an internal, systemic source.

2. Compilation of data: As a community, our goal is to compile data of our symptoms and possible triggers to look for patterns as the initial step for formal scientific research. All are encouraged to participate in MeBO Research and Arun's upcoming projects to achieve this goal.

3. Our 2009 Thames Festival Meet-Up: to take place on Saturday, September 12th and Sunday, September 13th in London –
a. Passports: WE NEED TO GET OUR PASSPORTS NOW; in the U.S., it takes about 2 months to process for 1st time applications.
b. A meet-up is likened to a pilgrimage: What an emotionally healing experience previous meet-ups like this one have been in such a beautiful setting, as we experience a strong sense of ‘belonging’, as opposed to our usual sense of being an ‘outsider’ in our every day social experiences.

One of MeBO Research’s aims is to promote social awareness of systemic body odor amongst the scientific/medical communities, and in the public and political spheres.4. Raising social awareness: One of MeBO Research’s aims is to promote social awareness of systemic body odor amongst the scientific and medical communities, and in the public and political spheres. Some of the members of the call have expressed an interest in participating in political lobbying and media exposure under the MeBO umbrella as a non-profit organization.

5. Strive for independence in self-management of our odor: Like any other type of physically challenging condition, a sufferer needs to manage his/her condition in as independent manner as possible. In the case of a body odor condition, the sufferer need to be able to identify her specific type of body odor with a personal scientifically-based device that can detect and identify the primary volatile compounds causing the odor, to be able to correlate it with the specific triggers in the environment (foods, chemicals, etc), and thus, the sufferer can make better choices to manage her condition without having to ask anyone for help or having to ask others, “Do I smell?”

Saturday, June 27, 2009

Inexpensive hydrogen sulfide urine test in Europe

The main problem in systemic body odor, especially fecal/gas/sewage/garbage etc body odors, is that at the moment no such condition is accepted by the medical system and so there is no testing for it. The only real exceptions being mainly trimethylaminuria, and rarely dimethylglycinuria (although it is unknown if more than one has been positive for this metabolite).

Until a pattern is known for 'fecal body odor', the obvious test would be for testing all odorous metabolites, such as a malodourous Volatile Organic Compound Urine test. At the moment this remains unobtainable from the medical system (although very possible to do), and so sufferers have to look around for other available tests.

Interestingly, a Belgian Professor with a long interest in Chronic Fatigue Syndrome, which many fecal body odor sufferers tend to have, has come up with a connection with CFS and hydrogen sulfide (H2S). H2S has often been mentioned on this blog, and is very much a suspect yet to be ruled out in fecal body odor syndrome in particular. Some fecal body odor sufferers have mentioned smelling of rotten eggs at times, which is most likely hydrogen sulfide.

Professor Kenny De Meirleir has now launched a very inexpensive hydrogen sulfide urine test in Europe, which would seem a worthy exploratory test at this stage of understanding fecal body odor as a group, under the premise of ruling it out. It is sold through his Belgian company, Proteo Biopharma

One caveat is that perhaps the test is looking for the metabolized/oxidized (neutralized) version of hydrogen sulfide, which is hydrogen sulfate (?), whereas in people with fecal body odor, perhaps the H2S is not oxidized. At the moment we don't know what metabolite the test is exactly looking for.

The website says the test is currently at a non-profit price (see the FAQ page) and is available to anyone in many countries including USA, Canada, Japan and Australia, as well as many European countries.

It would be very helpful if any fecal body odor sufferers let the group know their result somehow, whether by email to Maria, or on the body odor forums. In the future, MeBO Research hopes to do such tests in an informal case study manner. For instance, testing 5 people for this would cost around $200.


Daily Telegraph article on the hydrogen sulfide urine test
Other Daily Telegraph article on the hydrogen sulfide urine test
Proteo Biopharma Website

Friday, June 26, 2009

Create your own low-choline recipe on nutritiondata.com

In a recent post on the TMAU Yahoo Forum, A poster has posted a recipe using the nutrition data website, which allows you to calculate the nutrition of the recipe when constructing it, and in the case of TMAU therefore allows you to construct recipes low in choline, which TMAU sufferers are advised to keep low (as well as cruciferous vegetables, which are known to inhibit FMO3 enzyme).

Here is the post, with permission from the poster. Thank you

http://health.groups.yahoo.com/group/Trimethylaminuria/message/2157

People who are new to the Low Choline Diet may find this useful.

I created a recipe listing with nutritional data, for Chicken Fajita which is fairly low in choline (good for your main choline meal for the day / dinner).

http://www.nutritiondata.com/facts/recipe/1096639/2

100g of chicken as indicated is one rather large chicken breast. Peppers, Onion and flour tortillas are all low choline.

I'm not a very good cook, but even I can handle this recipe.

Scroll down to "Vitamins" and you will see Choline ~62mg, which is fairly low.

Best,

- Blue Sky Collector


This is also an opportunity to let people know that they can construct their own recipes on the nutritiondata website in the case of TMAU calculating it, especially for low choline content. By becoming a member, the recipe is then available to all readers of the site. Remembering that cruciferous vegetables are also advised to not be used for TMAU, since they are known to inhibit the FMO enzyme.

Note about the Chicken Fajita recipe : While the recipe technically easily fits the low-choline advice given by TMAU experts (and sounds very tasty), keeping in mind that cruciferous vegatables are also advised to be avoided, at the moment the range of smells that people report smelling of, including fecal/gas/sewage/garbage etc, seems more complicated than just trimethylaminuria. Also the issue of metabolic body odor is almost completely ignored by the medical system, so at this point it is unclear how people with metabolic body odors may metabolize foods such as garlic and onions, for example. People on the forums mention they have bad associations with many foods, such as sugar, sulfury food etc. So while the few experts in trimethylaminuria say that trimethylamine is all that the problem is, at the sufferer end of the spectrum this may not be the case.

Monday, June 22, 2009

Testing for Trimethylaminuria in Australia : One person's experience

A lady from Australia has kindly given permission for a post she did in the Rob's Yahoo TMAUcure forum to be reprinted here. It encapsulates the difficulties of the current process of TMAU testing in Australia, and gives an insight to the procedure. Thank you for allowing us to repost it.

It is posted so that Australians wishing to test can get an idea of what to expect, and also allows a comparison to other testing protocols throughout the world. For instance, a 'morning urine' sample is used, whereas Dr Fennessey in Denver seems to use a '24 hour period' sample.

I received a bill for my first urine test. It was $70. I did have a pathology slip so I don't know why I had to pay. Perhaps my doctor did not tick "bulk bill" on the slip. This urine test was sent from Victoria to Brisbane by the pathology company. The invoice says CaSS Pathology QLD. They test for TMA only, not TMA oxide.

A more reliable test is done in Adelaide, where they test for TMA oxide as well as TMA levels. It is done at the Royal Women's and Children's Hospital in Adelaide. I had mine sent from the Royal Children's here in Melbourne. I just rolled up with my pathology slip. Adelaide only accept urine samples from two hospitals in Australia. I am not sure where the other one is. If you would like further info, then send me an email. I did not receive a bill for the second test. I am not sure why, maybe it was because it was sent by a public hospital.

For both tests, all I needed was a pathology slip. My doctor used a Dorovitch slip. Both tests came back negative even though I loaded up for four previous days.

Urine must be frozen within an hour or so and kept frozen in transit.

---------------------
follow-up email: The writer wished to add more to her original post for clarification purposes. Thank you again for being so helpful.

I feel that what I wrote previously needs clarification. This is what I was advised to do:-

It is best if the urine sample is a morning sample (more concentrated). Use a container that holds around 100ml (the norm) and collect enough urine to almost fill it. Put the lid on straight away. It is best to do it at the collection centre where it can be frozen immediately and then kept frozen in transit. You must insist on this and perhaps write it on the container.

If distance from the centre is a problem, you can produce the sample at home. I was told that it is ok to refrigerate it for a short time until you are ready to leave. As long as the container is tightly sealed and not allowed to get above room temperature, there should be minimal loss over several hours. When you are leaving put it in an esky with ice and take it to the pathology/collection centre. It is best not to freeze it at home because it may defrost in transit. So leave the freezing to the collection/pathology centre or hospital.

I made up my own mind to load up with choline for four previous days but I was told to eat a meal containing fish or two eggs 1-2 hours before I collected the sample ie. breakfast.

Saturday, June 20, 2009

Body odor anthology : Final draft


Final draft : Conquering the invisble monster

Richard has recently posted the final draft of the body odor anthology on the body odor support forum, and here it is in PDF format. He is currently looking for a publisher. Thank you Richard for all the hard work; and to everyone who contributed. You are all helping us by raising awareness.

Wednesday, June 17, 2009

Conference call discussion: VBulletin and MEBO Research

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On our conference call held on Sunday June 14th, we discussed a wide spectrum of exciting upcoming events to come ranging from the changes we can expect in our Body Odor Support forum to our non-profit organization, MeBO Research, with aims to promote metabolic body odor research.

The community forum owner, Arun Nagrath, has just purchased a new VBulletin and VBulletin Blog for our Body Odor Support forum that he also founded on January 2009, which was designed and created for us by Matt and Kristen. The new VB will have many features, such as:

Could an FMO3 deficiency create a build up of multiple volatile compounds in addition to TMA in the case of TMAU, as well as in the absence of TMA as in the case of other body odor conditions, which are carried in our blood throughout our bodies?A new ‘Scientific Section’ in forum: In addition to having a gallery for photos, videos, music, literary works, art works, etc., VB will also allow for a Scientific Section, in which the opinions of experts and consultants invited by Arun could be posted, in addition to Arun’s own scientific opinions. This new VB will allow him to use a Database to organize data from past surveys and upcoming surveys to be answered by sufferers for it to be used in future scientific research and medical trials in an effort to find a cure.

The new VB Blogs will allow each member to have his/her own personal blog, similar to Facebook, where we can each design it very much as our own. In addition to this, our personal VB Blog can also serve as a personal diary, in which we would be able to write about (document) our experiences living with odor, whether in a school setting, work setting, visits to the doctor, setting, riding in the bus, reactions of our family and friends, etc.

Which are all the genes and metabolic enzymes involved in the various types of systemic body odor?
Medical causes behind body odor conditions: We raised many questions, such as, ‘Could an FMO3 deficiency create a build up of multiple volatile compounds in addition to TMA in the case of TMAU, as well as in the absence of TMA as in the case of other body odor conditions, which are carried in our blood throughout our bodies? Which are all the genes and metabolic enzymes involved in the various types of systemic body odor? To what extend does the bacteria in the whole digestive tract contribute to the buildup of our bloodborne body odorous compounds?’ These are the main questions that our new non-profit organization, MEBO Research was created to address.

To what extend does the bacteria in the whole digestive tract contribute to the buildup of our bloodborne body odorous compounds?

MEBO Research: Many questions were asked in the call about the developments of mebo, what its aims are, what type of research will mebo be pursuing, and how will the funds be handled. While funds are low, Mebo’s primary aims are to support research by initially funding smaller, less expensive, informal case studies to gather data to be used in future larger formal scientific research and medical trials. As funds grow, mebo will then be able to fund more expensive DNA testing focusing on FMO genes. Ultimately, it is mebo’s aspirations to be able to obtain an endowment to support a large-scale research effort that would seriously address any and all of the three questions mentioned above.

How will MEBO funds be spent, what type of research will be done? Since all these bank accounts currently have a zero balance, we can only begin by fund raising, and based on the funds accrued, efforts to answer the questions above-mentioned will be pursued. Initially, informal case studies will be organized to analyze and document the microbial composition of the colon, while protecting the privacy of the sufferer. As funds grow, mebo will also fund more expensive tests, such as DNA testing. All this will be done in an effort to gather as much data as possible to find trends and commonalities in the body odor sufferers microbial composition of the digestive tract, the metabolic enzymes that could play a role in systemic body odor, and the genes that govern these enzymes.

Transparency: All of mebo’s undertakings will be transparent, including but not limited to:

  • Funds raised: Fund balance reports will be posted in the website on a regular basis.
  • Expenditures: Expenditures will be kept at a minimum in an effort to make each and every venture as cost-effective as possible. Reports will be posted in the mebo website as expenses take place.
  • Test Results: All test results funded by mebo will be posted in the mebo website, protecting the privacy of the sufferer involved.

At the present time, the creation of MEBO Research is at its final stages, as the development of its website is being completed.

Saturday, June 13, 2009

Many new upcoming changes to be discussed in conference call

Old Faithful Geyser
Yellowstone National Park
video

Please join Arun and me, and many more of us in this community, on Sunday, June 14th’s Conference Call, in which we will be discussing a new alternate place to hold our conference calls in an effort to include our international members and friends. We are looking for a venue in which all our members could call in for free from anywhere in the world, so all can be a part of the conference call experience. Please join us to brainstorm in order to help us determine what the best options are.

Arun has good news for us about the big changes coming to our site and community soon. I’m looking forward to hearing all the details.

We may also discuss some of the topics brought up in the forum these past two weeks in the General and Support forums of our site, including the Body Odor, Science and Research, Helpful Products, Health, Diet and Exercise, Mental Health, Frustrated?, and Positive Thinking sections. Please bring your ideas, whether it’s just to highlight things said in these posts, or any information you may wish to add for further discussion on the call.


As always, there will also be time for open discussion.

For USA-based : (712) 432 1620;
Access Code 391629#
Non USA : prefix above with 001
but check to see if it is free with your supplier.
Bison near sulfur-odorous geyser

Hope to see everyone there!

María

Thursday, June 11, 2009

How we defined our son's odor

My husband and I have spent the last decade trying to understand an extremely strong odor that came from our son. He had always had much milder odor since his infancy, but it became extremely overwhelming when he turned 14 years of age, and he is currently 23 ½ years old.

...even though there was some sulfur scent in his odor, it wasn’t a pure sulfur odor, or a pure dead fish odor, or a pure fecal odor.
IT WAS A COMBINATION OF THEM ALL, and perhaps others as well!
Luckily, my husband has a much keener sense of smell than I do, and he can more readily discern and identify odors quite precisely. Being a saltwater fisherman by hobby since early childhood, my husband has been very much exposed to live, dead, fresh, and rotting fish in the hot tropical Caribbean and South Florida sun. He can easily identify all the various fish odors in these various states.

I have also been very much exposed to fish and decaying dead fish odor because I grew up in a freshwater-front home, and periodically there would be dead fish in the water that we could smell sitting in our back yard. Both my husband and I arrived at the conclusion that even though at times the odor coming from our son had traces of these fish odors, it was more than that.

Since puberty, I have personally experienced an odor coming from my own body, but I have always had difficulty identifying it. I also had acne on and off since puberty, and used sulfur-based topical creams on and off for years. Initially, I smelled the sulfur in these medicines, so I would apply it only at night to sleep. But eventually, I couldn’t smell the sulfur anymore. By the time I met my husband when I was 26 years old, he immediately smelled the sulfur on me even when I didn't have the creams on my skin. Not only did he smell it on my face, but on other parts of my body wherever I had perspiration or skin oils. So we can safely say that both my husband and I are very familiar with sulfur odor, so when our son began to emit this strong odor, it was most certainly not solely sulfur odor, although there were traces of sulfur odor as well.

I believe that all human beings are familiar with fecal body odor, and my husband has frequently described our son’s odor as fecal (and not as a matter of speech), yet not 100% fecal; there is a deeper odor to it that seems to accompany the fecal scent.

video


In an effort to better understand odors as well as to enjoy an overdose of natural beauty, my husband and I went on vacation to Yellowstone National Park two weeks ago. We were both very anxious to experience the ‘rotten egg’ sulfur odors that we had read and heard about that comes from the extreme temperature and acidic environment of the geysers, hot steamy sulfur pools (see video above), and mud volcanoes. We wanted to verify our identification and categorization of our son’s odor by smelling the unprocessed natural smell of sulfur and comparing.

The most interesting thing to me was that as we entered the park's west entrance, my husband smelled the sulfur long before I did and before we could even see the geysers, pools or mud volcanoes. I could smell it only when standing near them or with the wind blowing the mist in my direction. This also calls to mind how some parents, siblings, friends, etc., can not understand what a sufferer is even talking about because they don’t perceive their odor, or instead might perceive it mildly, while others at school or work find it extremely offensive.

This also calls to mind how some parents, siblings, friends, etc., cannot understand what a sufferer is even talking about because they don’t perceive their odor, or instead might perceive it mildly, while others at school or work find it extremely offensive. We both agreed that even though there’s a faint sulfur smell in my son's odor, it wasn’t a pure sulfur odor, or a pure dead fish odor, or a pure fecal odor. IT WAS A COMBINATION OF THEM ALL, and perhaps others as well!

This only raises more questions… people diagnosed with TMAU claim they don’t ONLY smell of fish. …people diagnosed with TMAU claim they don’t only smell of fish. COULD IT BE THAT THERE ARE MORE CHEMICALS INVOLVED AND/OR METABOLIC ENZYMES DEFICIENCIES THAN JUST THE ONE FMO3 ENZYME THAT OXIDIZES TMA?

COULD IT BE THAT THERE ARE MORE CHEMICALS INVOLVED AND/OR METABOLIC ENZYMES DEFICIENCIES THAN JUST THE ONE FMO3 ENZYME THAT OXIDIZES TMA?

Could there be multiple bacteria production of other compounds in our gut in addition to TMA that eventually our liver metabolic enzymes can’t metabolize, and thus flows freely through our bodies and comes out through our pores?

Could it be a result of a microbial imbalance, or possibly the presence of an unidentified micro-organisms in our digestive tract, including in the extreme environment of our very acidic stomachs (as there are in the Yellowstone sulfur pools), and or unidentified deficiency of other metabolic enzymes not yet identified?

WE NEED MORE RESEARCH!

THERE ARE TOO MANY UNANSWERED QUESTIONS…


María de la Torre

Wednesday, June 10, 2009

Short video about a hyperhidrosis case

video

Although this blog is mainly about external body odors, this short video is posted for those who feel they may have a hyperhidrosis issue.

Tuesday, June 9, 2009

Skype for free internet phone calls and conferences

NOTE
It has just been noticed that only 5 people can be in a Skype Conference, which greatly limits this as an option.
http://www.skype.com/intl/en/help/guides/skypeformac/skypefeatures/conference.html

With the coming of the internet, people with body odor or halitosis, especially systemic body odor, have at last found support throughout the world, and discovered they are not the only ones who have systemic body odor (and in fact, it seems not uncommon). Ways of communicating in different forms is good for the soul and also good for mobilizing action to find solutions to systemic body odor.

Nowadays with a computer and broadband connection, people can 'phone' other Skype members using their computer via Skype for free, anywhere in the world. It can also be used for free conference calls.

All that needs to be done is download the Skype program (Skype is owned by ebay) and have a microphone and headphones, then you open the Skype program and it will install itself in a simple manner. You also have to sign up to Skype (it's free and only requires a username and password) and then you will quickly see how to make free 'VoIP calls'. you can get a cheap mic/headset (the kind they use in call centers) from the likes of Walmart and thats all you need. You use your computer to make Skype calls (mic : mic socket, headphone : headphone socket)

With Skype you can call Skype members anywhere in the world for free by clicking on the icon on your desktop. the sound quality is far better than on the phone.

It also has the ability to do free phone conferences, where more than 2 people can talk in a 'conference room'

Skype makes its money by people signing up more fully for their other services, such as skype to landline.

There are many of these 'voice over IP' companies but Skype is the leader and very simple to get started with, as well as being free.

http://www.skype.com


What you needBroadband connection (probably)
Headset (mic and headphone like used in callcenter. Cheap ones are maybe $10 from Walmart)
Download Skype program
Register with Skype (username and password)
Install it
Click on Skype logo and make a call
BenefitsFree for skype to skype calls
Much better sound quality than phone
Contact anyone in the world
Can do Skype conferences


Skype help pages:
Call someone who's on Skype

Thursday, June 4, 2009

Mystery Diagnosis Trimethylaminuria episode being repeated this weekend

In the USA, Discovery Health is repeating the Mystery Diagnosis episode about Trimethylaminuria recently shown in Spring, featuring the case of Cheryl Marshall

The show can be seen this weekend at these times (please check) :

Sun 6/7
9:00-10:00pm

Mon 6/8
1:00-2:00am

Mystery Diagnosis
The Boy Who Stopped Walking
TV-PG

Rachele Lacount and Mike West are thrilled their baby Zach is walking and talking at 1year of age, when they notice his right eye has turned in. Cheryl Marshall, a typical eleven year old, begins to notice she is unusually smelly and sweaty.

Original Air date:
3/16/2009

The show is possibly available as an audio (video ?) download from Itunes.

Did you see the episode ?

Wednesday, June 3, 2009

Poll : If you tested, were you diagnosed as Primary Trimethylaminuria ?

If you tested, were you diagnosed as Primary Trimethylaminuria ?


Human olfactory psychophysics

This is a mainstream research paper about the sense of smell and is probably the current viewpoint of the mainstream on the olfactory system. It mentions concepts such as 'specific anosmia', 'threshold', and 'adaptation'. 'Specific anosmia' is the genetic inability to smell specific smells. Fecal body odor sufferers (or other bowel smells or other odd smells) often say they cannot smell themselves. This also seems to be the general rule for people with external body odor. However, those with fecal body odor can smell feces odor from other sources (not through human skin, it seems), so specific anosmia doesn't seem to be the reason. The same seems true for trimethylaminuria and probably other metabolic body odors, although Dr John Cashman believes that perhaps 8% cannot smell trimethylamine, although it's not known if he means only from humans or from any source. for example, most people seem to be able to smell fish. Another theory for this is 'adaptation' and desensitivity to the smell. This seems more likely than specific anosmia, however, perhaps sufferers have been in situations where a group of strangers complain of a smell but one stranger says they can't smell anything (for instance in school). Adaptation and desensitivity do not seem to account for this. At the moment it is a mystery. the most likely guess is that there is some genetic aspect, as of yet unknown.

That aside, the article is seemingly the 'latest' (2004) in olfactory perception and worth a read

Human olfactory psychophysics
Andreas Kellera and Leslie B. Vosshall 2004

Monday, June 1, 2009

Flagyl and Nystatin for fecal body odor ?

NOTE: in no way is this a recommendation or advice. It is suggested this will not work and may cause side effects. do your own research. Anyone who tries this does so at their own risk and are responsible for their actions.

Possibly a pattern is emerging, where someone with fecal body odor (or gas body odor or sewage body odor or however people perceive their 'bowel odor' problem to be) seems to also have what could be termed a 'gut issue' of some sort (whether it be bloating, gas, IBS, or however one wants to label the problem. In effect, a bowel issue that a doctor would not be interested in).

Since there is no research or recognition of this problem, obviously no guidance can be given as to whether what is known as 'fecal body odor' could be a gut issue alone. The guesses as to what could be the factors are never-ending at the moment. At one end of the spectrum is perhaps null-allelle homozygous mutants for FMO3, and the other end is someone with no accepted FMO issue and the problem is some sort of unique or multifactorial gut dysbiosis issue (such as secondary trimethylaminuria).

At the moment, a guess would be that someone may have one or more risky 'variants' of FMO3, and perhaps FMO3 plays a role in the colon in controlling the ecology. Perhaps the less 'severe' the DNA, the more it's to do with the gut ecology. in the end, the reason for smells is that seemingly an enzyme(s) is saturated with the smelly toxins. Anyone can smell of trimethylamine, given a big enough dose.

The best long-term approach would be to find out if there is a gut/FMO3 enzyme connection, and how much the gut issue is the factor, and if the dysbiosis is a unique type to this problem, or some sort of typical dysiobis.

For instance, some feel they have candida, but on candida boards you would be unlikely to find anyone that smells of feces. The point being, most with candida don't seem to smell. But perhaps candida is common amongst smellies, and the combination of the dysbiosis and the enzyme weakness is the 'sinker'. Or perhaps it is another pathogen to blame, as is suggested for trimethylaminuria. In this case they say it's a type of bacteria, but not which one. Speculation is that it will be the one that causes 'fish' vaginosis, which is thought to be gardnerella. or perhaps it is a parasite or some combination or some other bacteria.

While the best approach is research, some may look for treatment gambles. one gamble would be 'covering all bases' (in theory), such as taking nystatin and flagyl. The logic being, the nystatin will kill fungus, and the flagyl will kill anaerobic bacteria and protozoan parasites (in theory). This would be a 'scorched earth' policy. Flagyl is chosen since it is usually reasonably tolerated and cheap, but perhaps something like rifaximin would be better (since it isn't absorbed) but this is very expensive and probably impractical. Nystatin is not thought to be absorbed either, although it is unknown how much leaky gut would be a factor in absorption. Again chosen because it is relatively cheap. there is actually a vaginal suppository called 'flagylstatin' which seems to be using this approach for vaginosis, under the pretext they aren't sure whats causing it. Although it's probably wiser to buy the 2 medicines separately for gut conditions.

PLEASE NOTE THIS IS NOT ADVICE OR RECOMMENDATION SINCE NOBODY KNOWS WHAT CAUSES FECAL BODY ODOR, BUT IT IS POSTED SO THAT PEOPLE ARE AWARE OF CHOICES THEY THEMSELVES CAN MAKE. NO DOCTOR WOULD RECOMMEND THIS APPROACH. USE AT YOUR OWN RISK.

There are many possible downsides too, such as how does the gut ecology end up ? Or how long would it need to be taken ? or if there is any weakness in handling flagyl (it is known to interact with xenobiotic metabolizing enzymes. Also it is known to cause an 'antabuse' reaction (bad reaction to alcohol). There are known side-effects to flagyl including vomiting, dizziness, liver issues. Please research into flagyl to be aware of the issues.

The background of the post should be regarded as a desperate attempt to blindly solve 'gut dysbiosis' of an unknown sort. Testing is always the preference.