First UK baby screened for breast cancer gene born yesterday

Saturday, January 10, 2009

First UK baby screened for breast cancer gene born yesterday

This type of gentic manipulation seems to have started to come into use over the last few years, but in this case it was for a '%-risk' health problem.

It seems possible that if any gene was involved with metabolic odors, then future parents may have the opportunity to choose an embryo without the mutant/polymorphism DNA.

NewScientist blog article

FT.com article

concept: preimplantation genetic diagnosis (PGD)

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Regular FREE (long distance call plan) General and Women-only Phone Conferences

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access code : 391629#
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General Conferences: normally every other Sunday at 2pm EDT.
Next call : Sunday February 21th : 2pm EDT
Scroll down for next Women's conference
Women's Conferences: normally every other Thursday 8.30pm EDT. Next call: October 29th at 8:30p.m. EDT

Arranged by the leaders of the bodyodorsupport.com forum
Note: can also be used anytime for unscheduled group chats

Free USA-based phone conferences (if you have a long distance call plan. Otherwise you will be charged as a long-distance call)

For USA-based : (712) 432 1620 then type the access code on your phone keypad: 391629#
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If privacy is a concern, code your phone to PRIVATE mode
This phoneline can be used anytime to talk to other sufferers
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Thinktank

Bluesky ideas to promote thought:

PTC124(Ataluren, or similar) for primary TMAU due to nonsense mutations
Genetically modified probiotics enriched with FMO3 ?
Trimethylamine strip test paper for daily urine testing? (possibly used in the fish industry ?)
BO&Halitosis research center
BO&Halitosis research fund
Can FMO enzyme be induced in a helpful manner ?
Ask an expert if they will put up a Q&A section on their websites like Emory have
BO&Halitosis 'rehab' retreat (?)
TMAU cookbook/advice book
Employ an expert to do the most thorough choline list
Employ Body odor/halitosis expert(s) (?)
Encourage breath-analysis manufacturers to make portable handy analyzers for metabolic odor problems
TMA urine dipstick test
Is trimethylamine an FMO3 inhibitor ?
Campaign : add TMAU to the newborn screening program
Orphan drug program

Send in your ideas or post them on the forums: Contact experts

Peer evidence for experts

>Christodoulou Trimethylaminuria research proposal April 2009
> 2008 dissertation: 8 out of 12 TMAU phenotypes had no known FMO3 mutation
> 3.8% fail the TMAU urine test. pubmed paper 1996
> smell of schizophrenia
Neonatal with encephalopathy and later a # pungent cabbage odor. H2S and methanethiol in urine. Makes full recovery. (Anecdotal paper:1997)
> Portal shunt in girl. TMAU reported as only symptom
> Number of trimethylamine cases in random international samples
> Dimethylglycinuria. 1st (and only ?) reported case
> Orphanet on TMAU: The prevalence is estimated to be approximately 1 %
> Analysis of VOCs from skin
> Human breath odors and their use in diagnosis
> Results of Arun's Odor Survey

related papers

Bloodborne Body Odor and Halitosis

Saturday, January 10, 2009