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Friday, April 11, 2008

Diagnosis and management of trimethylaminuria (FMO3 deficiency) in children

Diagnosis and management of trimethylaminuria (FMO3 deficiency) in children

Journal of Inherited Metabolic Disease Volume 29, Number 1 / February, 2006
R. A. Chalmers, M. D. Bain, H. Michelakakis, J. Zschocke and R. A. Iles (
1) Paediatric Metabolism Unit, St George’s Hospital Medical School, London, UK
(2) Institute of Child Health, Aghia Sophia Children’s Hospital, Athens, Greece
(3) Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
(4) Department of Diabetes and Metabolic Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary College, London, UK
(5) Present address: CIMOA, London BioScience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK

Persistent trimethylaminuria in children is caused by autosomal recessively inherited impairment of hepatic trimethylamine (TMA) oxidation due to deficiency of flavin monooxygenase 3 (FMO3) secondary to mutations in the FMO3 gene...

full article:
http://www.springerlink.com/content/542235781n315104/

posted by Maria de la T., Founder and Executive Director, MEBO Research on 4/11/2008
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